This time was chosen because treatment-based differences in mean arterial pressure occurred early and remained constant throughout the treatment period and because only two confirmed serious thrombotic events had occurred by week 4 (one in each group). (function ($) { Elsewhere in this issue of the Journal, Nussmeier et al. AUGURI A TUTTI I CREMASCHI. Vakil, Aurora Sinai Medical Center, Milwaukee; P.R. Marcon, Toronto; R.D. Incidence of Adjudicated Thrombotic Adverse Events. } Ha subito il martirio nel 305 sotto l'imperatore Galerio. Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial. handcrafted in mexico. Am Heart J 2003;146:591-604, 6. Dr. Konstam reports having received consulting fees from Merck. I benedettini furono nei secc. We report the cardiovascular findings from the study. We report on the cardiovascular outcomes associated with the use of the selective COX-2 inhibitor rofecoxib in a long-term, multicenter, randomized, placebo-controlled, double-blind trial designed to determine the effect of three years of treatment with rofecoxib on the risk of recurrent neoplastic polyps of the large bowel in patients with a history of colorectal adenomas. Pressman, San Diego Digestive Disease Consultants, San Diego, Calif.; V. Prochazka, Fakultni Nemocnice Olomouc, Olomouc, Czech Republic; J.M. Kaplan–Meier estimates of the cumulative event rates over time were also made. Other investigator-reported cardiovascular events known to be associated with NSAID use, such as congestive heart failure and pulmonary edema, although less well defined, occurred earlier (at approximately five months) and at a higher rate among patients taking rofecoxib than among those taking placebo. The Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial was designed to evaluate the hypothesis that three years of treatment with rofecoxib would reduce the risk of recurrent adenomatous polyps among patients with a history of colorectal adenomas. Watson DJ, Rhodes T, Cai B, Guess HA. Venendo i Benedettini di Montecassino a Crema nel 1097 dovettero portare nel programma dell'ora et labora anche la devozione significativa del Monastero di Montecassino, cioè la devozione a San Pantaleone. Cleland, Montreal General Hospital, Montreal; G. Costamagna, Universita Cattolica del Sacro Cuore, Rome; P. Crone, Kobenhavns Amtssygehus i Glostrup, Glostrup, Denmark; E.V. function bsaProResize() { Anderson Cancer Center, Houston (R.S.B. }); if (d.getElementById(id)) return; Martinez, Hospital Militar Central, Bogota, Colombia; R. McLeod, Mount Sinai Hospital, Toronto; K.R. animateThumb.height(parentHeight); Ricorre oggi, 10 giugno, la festa per il Santo Patrono della Città di Crema, San Pantaleone. Information and tools for librarians about site license offerings. var sid = "5"; 1. C.F. The computer-derived randomization was stratified according to the clinical center and the use or nonuse of low-dose aspirin, with blocks of 2. Guess HA, Lydick EG, Small RD, Miller LP. Utilizziamo i cookie per essere sicuri che tu possa avere la migliore esperienza sul nostro sito. 46010 San Martino dall’Argine Patients who took at least 80 percent of their tablets during the placebo run-in period were randomly assigned to receive either one 25-mg tablet of rofecoxib per day (the maximal recommended long-term daily dose) or one identical-appearing placebo tablet per day for three years. }); Ma la storia di Crema ci documenta che il culto del martire Pantaleone è precedente al dominio di Milano e di Venezia: lo storico P. Terni ci tramanda che a Crema esisteva nel '200 un ospedale intitolato a S. Pantaleone e che una reliquia del cranio era custodita nell'antico altare del Duomo demolito nel 1486. Konstam, D. Bjorkman, R. Logan, H. Quan (nonvoting member); Adjudication Committees — Cardiology: L.S. Via Aldo Moro n.15 Selective inhibition of cyclooxygenase-2 (COX-2) may be associated with an increased risk of thrombotic events, but only limited long-term data have been available for analysis. A total of 3260 patients were screened for the study, of whom 2586 were deemed to be eligible; 1287 of the eligible patients were randomly assigned to receive rofecoxib, and 1299 to receive placebo (Figure 1). var number_show_ads = "0"; Marks, Alabama Digestive Research Center, Alabaster; C.E. Sikuli denuncia la lunga sofferenza della popolazione. Jensen, Centralsygehuset Esbjerg Varde, Esbjerb, Denmark; J.F. Infine, quando egli diede il suo consenso, gli fu tagliata la testa. Cucchiara, Rita; Grana, Costantino "Using the Topological Tree for skin lesion structure description" Knowledge-based Intelligent Information Engineering Systems & Allied Technologies, Podere d'Ombriano, Crema, Italy, pp. innerThumb.height(parentHeight); } Lower risk of thromboembolic cardiovascular events with naproxen among patients with rheumatoid arthritis. Kim, University of Chicago Medical Center, Chicago; P. Knoflach, AKH Barmherzige, Schwestern vom heiligen Kreuz, Wels, Austria; M. Koch, Capital Gastroenterology Consultants, Silver Spring, Md. The risk of cardiovascular thrombotic events with selective cyclooxygenase-2 inhibitors. The two groups were generally similar with regard to baseline characteristics, including age, sex, use or nonuse of low-dose aspirin, and cardiovascular-risk status (Table 1). setTimeout(function () { bsaProContainer.fadeOut(); }, number_hide_ads * 1000); The advent of the Internet of Things (IoT) has led to a proliferation of cyber-parts and associated systems, i.e. Pantaleone è oggetto di venerazione in Oriente, dove viene chiamato “il grande martire” ed è invocato come taumaturgo. A total of 2586 patients with a history of colorectal adenomas underwent randomization: 1287 were assigned to receive 25 mg of rofecoxib daily, and 1299 to receive placebo. Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. innerThumb.height(parentHeight); setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); N Engl J Med 2005;352:1081-1091, 29. Utilizziamo i cookie per essere sicuri che tu possa avere la migliore esperienza sul nostro sito. Nel secolo scorso avvenne la donazione da parte dell'Ospedale al Duomo di Crema. The relative risks of a confirmed thrombotic event in the rofecoxib group, as compared with the placebo group, were broadly similar across quartile categories of the change in blood pressure (data not shown). ], 11. js = d.createElement(s); js.id = id; Sandler, R. Riddell, D. Morton, A. Lanas, B. Oxenius (nonvoting member), J.A. Arthritis Rheum 2000;43:4-13, 3. Stay connected to what's important in medical research and clinical practice, Subscribe to the most trusted and influential source ofmedical knowledge, A correction has been published setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); L’imperatore avrebbe voluto risparmiarlo e cercò di persuaderlo ad abiurare. Liebermann, Radiant Research, Austin, Tex. the perfect way to enjoy patrÓn is responsibly. var sid = "13"; Kaplan–Meier Estimates of the Cumulative Incidence of Confirmed Serious Thrombotic Events. In post hoc analyses, the increased relative risk of adjudicated thrombotic events was first observed after approximately 18 months of treatment. if ( objectWidth > 0 && objectWidth != 100 && scale > 0 ) { Venne scelto come patrono dalla comunità civile cremasca dopo la sua misteriosa apparizione sulla città per liberarla dalla pestilenza il 10 giugno 1361. Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly. The three most common adverse events resulting in the discontinuation of treatment were hypertension (25 patients in the rofecoxib group and 7 patients in the placebo group), increased blood pressure (6 in the rofecoxib group and 1 in the placebo group), and peripheral edema (7 in the rofecoxib group and 1 in the placebo group). deDios, Hospital Universitario Reina Sofia, Cordoba, Spain; A. Giacosa, Instituto Nazionale Per La Ricerca Sul Cancro, Genoa, Italy; M.J. Goldstein, Long Island Gastro Intestinal Research Group, Great Neck, N.Y.; F. Gomollon-Garcia, Hospital Universitario Miguel Servet, Zaragoza, Spain; P. Gandrup, Aalborg Syenhus, Aalborg, Denmark; A. Habr-Gama, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo; M. Haque, S. Parry, Middlemore Hospital, Auckland, New Zealand; R. Hardi, Metropolitan Gastroenterology Group, Chevy Chase, Md. Whelton A, White WB, Bello AE, Puma JA, Fort JG. var animateThumb = $(".bsaProContainer-" + sid + " .bsaProAnimateThumb"); Drs. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. Schubert, Allenmore Medical Center, Tacoma, Wash.; H.I. if ( objectWidth < parentWidth ) { Ray WA, Stein CM, Daugherty JR, Hall K, Arbogast PG, Griffin MR. COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. DOI: 10.1056/NEJMoa050493, Tap into groundbreaking research and clinically relevant insights. CAPITALE SOCIALE Euro 100.000,00 i.v. The end point used in the Antiplatelet Trialists' Collaboration (APTC) study23 was also analyzed: the combined incidence of death from cardiovascular, hemorrhagic, and unknown causes; nonfatal myocardial infarction; and nonfatal ischemic and hemorrhagic stroke. The institutional review board at each center approved the study. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. } La reliquia del braccio ha una storia che si inserisce anche nelle vicende dell'Ospedale di Crema. bsaProResize(); Harris, N.B. Only the 1000 most recent citing articles are listed here. }); Nussmeier NA, Whelton AA, Brown MT, et al. Con la costituzione della diocesi san Pantaleone rimase il patrono principale, come lo era stato per la città e territorio nei due secoli precedenti, anche se il nome del santo martire non è scritto nella bolla pontificia di papa Gregorio XIII Super universas dell'11 aprile 1580. ; W. Harford, Veterans Affairs Medical Center, Dallas; S.M. Effects of celecoxib and rofecoxib on blood pressure and edema in patients ≥65 years of age with systemic hypertension and osteoarthritis. Follow-up of the patients for one year after the discontinuation of treatment is ongoing. Oggi è la solennità del patrono di Crema, san Pantaleone, medico e martire. Baseline Characteristics of the Patients. Le reliquie del Santo Patrono custodite a Crema, in Duomo, sono due. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. animateThumb.height(parentHeight); Baron JA, Cole BF, Sandler RS, et al. ; R.W. var number_hide_ads = "0"; Calcio Serie C: Pergolettese, mister Contini rassegna le dimissioni, Calcio a 5: rinviata la partita del Videoton di domani. CTRL + SPACE for auto-complete. Ricorre oggi, 10 giugno, la festa per il Santo Patrono della Città di Crema, San Pantaleone. Calcio a 5: protesta pacifica del Videoton prima della partita, Calcio Serie C: la nebbia costringe al rinvio la Pergolettese, IV Giornata mondiale dei poveri – Papa Francesco: “La più grande povertà da combattere è la nostra povertà d’amore”, Diocesi di Butembo Beni – Mons. Risk of acute myocardial infraction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study. No formal stopping rule was specified for terminating the study. Il Nuovo Torrazzo fruisce dei contributi statali diretti di cui alla Legge 7 agosto 90 n. 250. ); the Department of Pathology, Mount Sinai Hospital, Toronto (R.R. Mamdani M, Rochon P, Juurlink DN, et al. The possibility that conventional NSAIDs may have similar effects also has to be considered. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030-4009, or at [email protected]. (H.Q., J.A. object.height(parentHeight); Pantaleone, però, confessò apertamente la sua fede e, per mostrare di essere nel giusto, risanò un paralitico: ciò nonostante, egli fu dapprima condannato al rogo, ma le fiamme si spensero, poi ad essere immerso nel piombo fuso, ma il piombo si raffreddò miracolosamente; a questo punto Pantaleone fu gettato in mare con una pietra legata al collo, ma il masso prese a galleggiare; venne condannato ad feras, ma le belve che avrebbero dovuto sbranarlo si misero a fargli le feste; fu poi legato ad una ruota, ma le corde si spezzarono e la ruota andò in frantumi. Quan, Oxenius, Horgan, and Lines are employees of Merck, and Drs. Spouse of the Blessed Virgin Mary Legal father of Jesus Prince and Patron of the Universal Church; Venerated in: All Christian denominations which venerate saints: Feast: 19 March – Saint Joseph, Husband of Mary (Western Christianity) The third Wednesday after Easter Sunday-The Solemnity of Saint Joseph, spouse of the Blessed Virgin Mary and Patron of the Universal Church (Roman Catholic Church) var animateThumb = $(".bsaProContainer-" + sid + " .bsaProAnimateThumb"); Eu, Singapore General Hospital, Singapore; N.R. 1. report that patients who received parecoxib and valdecoxib for pain in the first 10 days after coronary-artery bypass grafting had an increased risk of cardiovascular events during 30 days of follow-up.28 Also in this issue, Solomon et al. object.height(parentHeight * scale); Locatelli lascia per…, IV Giornata mondiale dei poveri – Papa Francesco: “La più grande…, Cattedrale di Crema: preghiera per le vocazioni [video], Cardinale Bassetti è stato dimesso dalla terapia intensiva, DIOCESI – Esercizi spirituali per laici, preti e consacrati, Papa Francesco – La preghiera perseverante, come ossigeno della vita, Nagorno-Karabakh: appello Chiesa apostolica armena, “salviamo dalla distruzione chiese e monasteri…, Inflazione – Coldiretti: “Aumentano i prezzi al consumo nel carrello della…. var object = $(".bsaProContainer-" + sid + " .bsaProItemInner__img"); URP - Ufficio Relazioni col Pubblico LE RELIQUIE Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib. bsaProResize(); Valuable tools for building a rewarding career in health care. Association between naproxen use and protection against acute myocardial infarction. var objectWidth = object.width(); The second analysis included changes from baseline in mean arterial pressure as a time-varying covariate in a Cox proportional-hazards model in which treatment was the main effect. The mean duration of treatment was 2.4 years in the rofecoxib group and 2.6 years in the placebo group. Eskreis, R.E. Il “megalomartus”, il grande martire Pantaleone, come viene ancora oggi invocato nella liturgia bizantina, conserva nella devozione benedettina un posto d'onore. An updated analysis that included data from various placebo-controlled studies investigating rofecoxib for the treatment or prevention of Alzheimer's disease did not demonstrate an excess of cardiovascular events associated with rofecoxib therapy.5 A recent meta-analysis comparing cardiovascular risk in trials that included various doses of rofecoxib suggested an increased relative risk among patients taking rofecoxib, as compared with those taking naproxen, but not placebo.22 Differences between our results and these earlier clinical-trial data may be related to differences in defined end points or the duration of treatment, a possibility supported by the apparent absence of a difference in adjudicated thrombotic events during the first 18 months of our study. Ann Intern Med 2005;142:157-164, 28. $(window).resize(function(){ Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. – R.I. Cremona 00351480199 – NUMERO REA CR – 99726 function bsaProResize() { Circulation 2004;109:2068-2073, 8. bsaProResize(); innerThumb.height(parentHeight); One analysis summarized the relative risk of confirmed serious thrombotic adverse events according to the quartiles of change in mean arterial pressure at week 4.
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